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METHADOSE is contraindicated in patients with regarded or suspected gastrointestinal obstruction, such as paralytic ileus. The methadone in METHADOSE may possibly result in spasm from the sphincter of Oddi.Supportive treatment is usually furnished for neonates with milder conditions. Pharmacologic intervention is applied when reasonable to intense

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The observed deficiency of an important accumulation of PHN in brain subsequent the intraventricular administration of (+)-amphetamine as well as development of considerable amounts of PHN from (+)-POH in brain tissue in vivo supports the view which the aromatic hydroxylation of amphetamine following its systemic administration happens predominantl

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